Ouvrages

2024

• OS - Ouvrages scientifiques

  Understanding the role of polyunsaturated fatty acids in the development and prevention of cancer

  Akbar, S., Rahman, A., Ahmad, N., Muhammad, I., Hafeez, Z.

  See the abstract Consulter le lien

  Polyunsaturated fatty acids (PUFAs), notably omega-3 (n-3) and omega-6 (n-6), have received much attention owing to their multifaceted effects not only in the management of diverse pathological conditions but also in the maintenance of overall health of an individual. A disproportionately high n-6 to n-3 ratio contributes to the development of various disorders including cancer, which ranks as a leading cause of death worldwide with profound social and economic burden. Epidemiological studies and clinical trials combined with the animal and cell culture models have demonstrated the beneficial effects of n-3 PUFAs in reducing the risk of various cancer types including breast, prostate and colon cancer. The anti-cancer actions of n-3 PUFAs are mainly attributed to their role in the modulation of a wide array of cellular processes including membrane dynamics, apoptosis, inflammation, angiogenesis, oxidative stress, gene expression and signal transduction pathways. On the contrary, n-6 PUFAs have been shown to exert pro-tumor actions; however, the inconsistent findings and controversial data emphasize upon the need to further investigation. Nevertheless, one of the biggest challenges in future is to optimize the n-6 to n-3 ratio despite the genetic predisposition, age, gender and disease severity. Moreover, a better understanding of the potential risks and benefits as well as the cellular and molecular mechanisms of the basic actions of these PUFAs is required to explore their role as adjuvants in cancer therapy. All these aspects will be reviewed in this chapter.

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Communications

2012

• C-ACTI - Communications avec actes dans un congrès international

  Link between the lipolysis stimulated lipoprotein receptor and lipogenesis in the liver

  Arteriosclerosis, Thrombosis, Vascular Biology 2012, 18-20 Avril, Chicago, Etats Unis.

  Hanse, M., Stenger, C., Akbar, S., Pinçon, A., Yen, F.T.

2011

• C-ACTI - Communications avec actes dans un congrès international

  Link between the key lipogenic enzyme ATP citrate lyase and hepatic receptor for triglyceride-rich lipoproteins, the lipolysis stimulated lipoprotein receptor

  FEBS Congress, 25-30 Juin, Turin, Italie.

  Hanse, M., Stenger, C., Akbar, S., Malaplate-Armand, C., Olivier, J.-L., Oster, T., Yen, F.T.
• C-ACTI - Communications avec actes dans un congrès international

  Peripheral regulation of hepatic lipolysis stimulated lipoprotein receptor by leptin

  FEBS Congress, 25-30 Juin, Turin, Italie.

  Stenger, C., Hanse, M., Akbar, S., Oster, T., Yen, F.T.

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